COMPARATIVE EVALUATION OF ANTIBACTERIAL ACTIVITY OF (ACACIA) HONEY AND COMMONLY USED ANTIBIOTICS AGAINST KLEBSIELLA SPECIES ISOLATED FROM UTI PATIENTS
DOI:
https://doi.org/10.59365/hsj.4(1).2025.177Keywords:
Acacia honey, Klebsiella species, Klebsiella Pneumoniae, Urinary tract infections (UTIs), Multidrug resistance (MDR), Antibacterial activity, Disc diffusion method, Minimum Inhibitory Concentration (MIC),Abstract
Background: Urinary tract infections (UTIs) caused by Klebsiella species present a growing public health challenge because of increasing multidrug resistance. The antibacterial effectiveness of Acacia honey against Klebsiella Pneumoniae isolated from UTI patients is assessed in this study in comparison to routinely used drugs.
Methods: Thirty urine samples in all were gathered and subjected to culture, gram stained, and biochemical analysis in order to identify the bacteria. Antibacterial assay to check the susceptibility of standard antibiotics and efficacy of honey.
Findings : Results indicated that Acacia honey exhibited a significantly larger zone of inhibition (20 mm) compared to conventional antibiotics, including ciprofloxacin (10.2 mm), doxycycline (10.1 mm), and no inhibition by ampicillin, aztreonam, and chloramphenicol. These findings suggest that Acacia honey holds promise as an alternative or complementary treatment for multidrug-resistant Klebsiella infections, warranting further exploration of its clinical applications.
Recommendation: Future perspectives are recommended that there is a lack of molecular studies as to how honey can exert its antimicrobial activity at a molecular level e.g. disruption of the cell walls, prevention of biofilm formation or interference with bacterial enzymes.
