COMPARATIVE HEALING OF FULL THICKNESS CUTANEOUS WOUND IN RABBIT BY USING OINTMENT OF NANOPARTICLES ZINC OXIDE AND COMMERCIAL AVAILABLE ONES

Abstract

Background: The primary defensive line of body is skin when any discontinuity or violence occurs, lead to wound formation. These wounds majorly termed as close & open wounds. The skin automatically starts the healing process. But this process of healing may be delayed due to any infection or contamination. Many antiseptic agents available to prevent these infections, decrease-healing time when applied topically on wound site like zinc oxide .Objectives: The research was aimed to check, comparative therapeutic efficiency of ointment of nanoparticles of zinc oxide with the ointment of commercially available zinc oxide in the healing of full thickness cutaneous wound. Animals: 15 sound & healthy rabbits were selected for this research. Methods: For single experiment, dorsum of the single rabbit was selected as the site where the wound was inflicted. After that ointment of nanoparticles of ZnO, the ointment of ZnO (commercially available) & typical normal saline were used to treat the wound. Therapeutic efficacy of agents were checked by noting contraction rate of wound, time of healing & histopathological examination. To analyze the generated data of this experiment, ANOVA was used. Results: it was noted that ointment of nanoparticles of Zn₂O show better results than other 2 agents.

Conclusions: The wounds treated by ointment of nanoparticles of Zn₂O show less time of healing, had superior content of collagen fibers, huge vascularization at the site of wound that justify the good efficiency of Zinc oxide nanoparticles ointment.